Some women take a type of hormone therapy called BHRT with a lot more estriol than usual—this might be just as risky for the heart as regular hormone therapy, but we just don’t have enough proof yet to say for sure.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Is Bio-Identical Hormone Replacement Therapy Safer than Traditional Hormone Replacement Therapy?

Narrative Review

2006

This study says that even though some people think natural hormones are safer, they might still be risky for the heart — just like regular hormone pills — and we don’t have enough proof yet to say they’re safe.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Is Bio-Identical Hormone Replacement Therapy Safer than Traditional Hormone Replacement Therapy?

Score: 1

DOI: 10.2165/00024677-200605060-00005

Similar Assertions

We don’t have enough solid studies to know if oral bio-identical hormones like estriol are safe for the heart, so doctors shouldn’t recommend them until we do.

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80%

Estriol is a hormone used in some types of hormone therapy, and doctors give it in much bigger doses than in regular hormone treatments—but we don’t really know how it affects heart health, and it seems to act differently in different people.

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74%