People’s cholesterol levels react differently when they swap out saturated fats in their diet, and this might be why studies can’t agree on whether eating more saturated fat increases heart disease risk.

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Evidence from Studies

Supporting (1)

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Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk?

Narrative Review

2021 Jul

Some people’s cholesterol goes down a lot when they eat less saturated fat, while others barely change — this study says that difference might be why big studies can’t agree if saturated fat causes heart disease: it’s not that fat doesn’t matter, but that it only helps some people.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Does variation in serum LDL-cholesterol response to dietary fatty acids help explain the controversy over fat quality and cardiovascular disease risk?

Score: 1

DOI: 10.1016/j.atherosclerosis.2021.03.024

Similar Assertions

People’s cholesterol levels react differently when they swap out saturated fats in their diet, and this difference might be why studies can’t agree on whether eating more saturated fat increases heart disease risk.

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100%

Multiple large-scale meta-analyses of prospective cohort studies demonstrate no statistically significant association between dietary saturated fat intake and incidence of coronary heart disease or cardiovascular disease.

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81%

Eating foods with saturated fat, like butter or meat, doesn't seem to raise your risk of heart disease or dying from it, based on the studies reviewed.

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79%

If you're at risk for metabolic problems, swapping butter or fatty meats for olive oil or avocados doesn't drop your 'good' cholesterol as much as swapping them for bread or sugar.

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79%

Even when researchers accounted for how many total calories people ate or how much other fats they consumed, the link between saturated fat and heart disease still didn’t show up.

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79%