In adults with obesity and prediabetes, taking 1.8 mg of liraglutide daily increases feelings of fullness and reduces self-reported desire to eat later, but does not lower the actual amount of...
Mechanism
Synthesis from 1 study
Liraglutide activates brain receptors that signal fullness, making people feel satisfied and less inclined to eat more later. This changes how full they feel and how much they think they want to eat, but it does not change how much food they actually consume.
Most probable mechanism
Liraglutide binds to special receptors in the brain that detect fullness, which turns on signals that make a person feel satisfied and less interested in eating more food later, even though the actual amount of food eaten doesn't change.
Liraglutide binds to glucagon-like peptide-1 receptors on glutamatergic neurons in the hypothalamus
Activation of these neurons increases neural signaling that promotes satiation and sustained satiety
Enhanced satiety signaling reduces the subjective perception of prospective food consumption without altering actual energy intake
Evidence from Studies
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Contradicting (1)
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