When young men eat way less food than normal and take a high dose of testosterone, their brains react differently when they get angry, they feel angrier during tests, their hormone levels drop, and their blood gets thicker—but no major side effects happened.

A double-blind, placebo-controlled RCT in healthy young men (18–30 years) with induced severe caloric deficit (≤15 kcal/kg/day) for 8 weeks, comparing supraphysiological testosterone (200 mg/week IM) vs. placebo, measuring fMRI brain activation during standardized provocation tasks, self-reported anger scales, serum gonadotropins, hemoglobin, hematocrit, and adverse events.

A crossover RCT in the same population, where each participant receives both testosterone (200 mg/week) and placebo in randomized order, separated by a 4-week washout, with identical outcome measures (fMRI, anger scores, hormones, blood counts) to control for individual variability.

A prospective cohort study tracking young men on severe caloric deficit who self-select into testosterone use (200 mg/week) or no testosterone, with matched baseline characteristics, measuring changes in brain activation (fMRI), anger reports, hormone levels, and hematologic parameters over 8–12 weeks.

A case series of 10–15 young men undergoing severe caloric deficit and receiving 200 mg/week testosterone, with standardized assessments of brain activation (fMRI), anger responses, hormone levels, and hematologic markers before and after intervention.

A retrospective analysis of medical records from clinical settings where young men received supraphysiological testosterone during intentional weight loss (e.g., athletes, bodybuilders), extracting data on anger reports, hormone levels, hematocrit, and adverse events.