Taking L-arginine or L-arginine plus sodium butyrate didn’t change blood sugar levels after eating in obese people — even though it raised one appetite hormone.

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Evidence from Studies

Supporting (1)

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The effect of oral l-arginine alone or in combination with sodium butyrate on glucagon-like peptide-1 secretion in non-diabetic adults with obesity.

Randomized Controlled Trial

Human

2025 Jul 7

The study gave people with obesity either L-arginine, L-arginine plus sodium butyrate, or nothing, then checked their blood sugar after eating. In all cases, their blood sugar stayed about the same—so the supplements didn’t change it.

Contradicting (0)

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No contradicting evidence found

Source Study

The effect of oral l-arginine alone or in combination with sodium butyrate on glucagon-like peptide-1 secretion in non-diabetic adults with obesity.

Score: 44

DOI: 10.1177/02601060251356584

Similar Assertions

The combo of L-arginine and sodium butyrate raised the appetite hormone more than L-arginine alone — but we don’t know if that difference was real or just luck.

90%

Even though the supplements raised a hormone linked to fullness, people didn’t feel any less hungry or more full after eating.

85%

Giving obese people a one-time mix of L-arginine and sodium butyrate before eating made their body release more of a hormone (GLP-1) that helps control blood sugar and appetite — but only for that one meal.

79%

Taking just L-arginine before a meal might slightly raise the appetite-regulating hormone GLP-1 in obese people, but the result was too weak to be sure it wasn’t just random chance.

76%