Analysis Version
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History
Back to Study: Ergogenic effects of a 10-day L-citrulline supplem...
causal
Strong Support

Taking L-citrulline pills for 10 days doesn’t help healthy, moderately active young adults ride harder or longer on a bike at a tough pace.

53
Pro
0
Against

Evidence from Studies

Supporting (2)

53

Community contributions welcome

53

Ergogenic effects of a 10-day L-citrulline supplementation on time to exhaustion and cardiorespiratory and metabolic responses in healthy individuals: a double-blind, randomised, placebo-controlled crossover trial

Randomized Controlled Trial
Human
2025

Scientists gave people L-citrulline for 10 days and had them cycle until exhaustion — just like the claim said. They found no improvement in how long people could cycle, so the supplement didn’t help.

53

Ergogenic effects of a 10-day L-citrulline supplementation on time to exhaustion and cardiorespiratory and metabolic responses in healthy individuals: a double-blind, randomised, placebo-controlled crossover trial

Randomized Controlled Trial
Human
2025

Scientists gave people L-citrulline for 10 days and had them cycle until exhaustion — they didn’t last any longer than when they took a sugar pill, so the supplement didn’t help.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Ergogenic effects of a 10-day L-citrulline supplementation on time to exhaustion and cardiorespiratory and metabolic responses in healthy individuals: a double-blind, randomised, placebo-controlled crossover trial

Score: 53
DOI: 10.3389/fspor.2025.1627743

Similar Assertions

Taking a specific amino acid supplement called L-citrulline for 10 days might help young women bike harder for a little longer, but the results weren’t strong enough to be sure — so scientists think it might work differently for women than for men, and more research is needed.

53
0
89%

Taking a specific dose of L-citrulline for 10 days doesn’t make you bike harder, faster, or feel less tired—even though some people think it might help. Your heart, lungs, and muscles act the same as if you didn’t take it.

53
0
87%

Taking a specific amino acid called L-citrulline every day for a week, plus a little more before a bike race, helps men who are already fit ride harder for 4 kilometers without getting more out of breath — meaning their bodies use energy more efficiently.

66
0
86%

Taking a specific dose of L-citrulline for 10 days doesn’t change how your body uses sugar or handles lactic acid when you bike really hard, so it doesn’t help or hurt your energy or fatigue during intense exercise.

53
0
85%

Taking a supplement called L-citrulline every day for a week, plus a little more right before riding a bike for 4 km, makes healthy, fit men feel less tired and more focused right after they finish the ride.

66
0
85%