Taking nitroglycerin for a long time can make your blood vessels produce too many harmful molecules, which stops the drug from working properly and makes your blood vessels less healthy—this is why the medicine stops helping over time.

1

Pro

0

Against

Evidence from Studies

Supporting (1)

1

Community contributions welcome

1

Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress

Narrative Review

2015 Oct 10

This study shows that taking nitroglycerin for a long time makes harmful molecules (ROS) build up in blood vessels, which breaks down the body’s ability to use the drug properly and causes blood vessels to stop responding — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress

Score: 1

DOI: 10.1089/ars.2015.6376

Similar Assertions

Your body uses a specific enzyme called ALDH-2 to turn nitroglycerin (a heart medicine) into something that helps relax blood vessels. But if your body is under stress and produces too many harmful molecules, this enzyme gets blocked — which is why the medicine stops working as well over time.

1

0

73%

A molecule called nitric oxide helps your blood vessels relax, your heart pump better, and your cells make energy properly — when this system goes wrong, it can lead to high blood pressure and heart problems.

1

0

73%