Taking tesamorelin for a year doesn't change blood sugar, insulin levels, or insulin resistance in obese people with low growth hormone.

The drug didn’t make blood sugar or insulin levels better, so its benefits must come from somewhere else — likely directly on muscle energy production.

Taking tesamorelin for a year makes IGF-I levels rise much more in obese people with low growth hormone than taking a dummy pill, with a clear difference between the two groups.

Taking tesamorelin for a year makes the hormone IGF-I go up much more in obese people with low growth hormone compared to taking a sugar pill.

After a year of treatment, tesamorelin didn't show a clear improvement in muscle energy recovery compared to a placebo in obese people with low growth hormone.

In obese people with low growth hormone taking tesamorelin, the link between higher IGF-I and better muscle energy recovery is even stronger than in the whole group of participants.