If a pregnant woman takes too much folic acid—more than 1000 micrograms a day—and her blood has very high levels of folate and B12, her baby might be more likely to develop autism, as if these nutrients together are sending mixed signals to the developing brain.

Evidence from Studies

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Adverse Effects of Excessive Folic Acid Consumption and Its Implications for Individuals With the Methylenetetrahydrofolate Reductase C677T Genotype

Narrative Review

2025 Feb

The study says too much folic acid can be bad, especially for some moms with a specific gene, but it doesn’t say anything about autism or the exact levels of folate and B12 mentioned in the claim.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Adverse Effects of Excessive Folic Acid Consumption and Its Implications for Individuals With the Methylenetetrahydrofolate Reductase C677T Genotype

Score: 1

DOI: 10.7759/cureus.79374

Similar Assertions

If you eat too much folic acid (a B vitamin found in supplements and fortified foods), it can hide the early blood signs that you're low on vitamin B12, so doctors might not catch the problem until your nerves are already damaged.

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