A heart medication called propranolol might help slow down bone breakdown in people with an overactive thyroid, based on changes in a specific substance found in their urine.

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Evidence from Studies

Supporting (1)

20

Community contributions welcome

20

Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: a beta-receptor blockade effect or a membrane stabilizing mechanism?

Cross-Sectional Study

The study shows that propranolol lowers a substance in urine (hydroxyproline) that comes from breaking down bone collagen in people with overactive thyroids, which supports the idea that it affects bone breakdown.

Contradicting (0)

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Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Reduction by propranolol of urinary hydroxyproline excretion in human hyperthyroidism: a beta-receptor blockade effect or a membrane stabilizing mechanism?

Score: 20

DOI: 10.1016/0026-0495(84)90123-9

Similar Assertions

If someone has an overactive thyroid, taking propranolol might lower a certain waste product in their urine, and this probably happens because of how the drug affects cell walls, not because of its usual heart-slowing effects or changes to thyroid hormones.

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When people have an overactive thyroid, a drug called propranolol lowers a bone breakdown marker in their urine — but it doesn’t do this by changing levels of a key thyroid hormone.

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80%