A chemical called Atglistatin works really well to block a fat-burning enzyme in mice—by 95%—but it barely does anything to the same enzyme in humans, so it probably won’t work as a weight-loss drug for people.

Evidence from Studies

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No supporting evidence found

Contradicting (1)

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Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Cohort Study

Animal

2017 Mar 22

The study shows that a drug called Atglistatin works well in mice to improve their metabolism, but it doesn't test whether the drug works the same way in humans — so we can't say if the claim about it failing in humans is true or not.

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Source Study

Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice

Score: 13

DOI: 10.1038/ncomms14859

Similar Assertions

When scientists block a fat-burning enzyme called ATGL with a drug in mice, their hearts don’t get fatty or stop working—unlike when the enzyme is missing from birth, which causes serious heart problems.

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