The IGF-1Ec peptide in humans and its equivalent in rodents are naturally produced in the body within tissues such as muscle, liver, and heart, alongside a larger precursor molecule, and are generated as part of the normal activity of the IGF-1 gene.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans.

Cross-Sectional Study

Human & Animal

2017 Feb

Scientists found that the body naturally makes a small piece called IGF-1Ec (and its mouse version Eb) while making a bigger protein, and this happens in muscles, liver, and heart—meaning it’s not just a lab idea, it’s real biology.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Identification of the IGF-1 processing product human Ec/rodent Eb peptide in various tissues: Evidence for its differential regulation after exercise-induced muscle damage in humans.

Score: 20

DOI: 10.1016/j.ghir.2016.11.001

Similar Assertions

A specific protein precursor called pro-IGF-1Ec is cut by an enzyme named furin in human muscle and liver, resulting in a smaller fragment known as the Ec peptide. This indicates a biochemical process that modifies the protein after it is made.

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