The mice didn’t gain or lose weight or eat differently with the drug, so the benefits aren’t just because they were eating less or changing their metabolism.
Scientific Claim
In apolipoprotein E-deficient mice on a high-fat high-cholesterol diet, MPE-298 treatment is associated with no significant change in body weight or food intake compared to vehicle controls, indicating that metabolic effects are not confounding the observed outcomes.
Original Statement
“Azapeptide treatment had no observable effect on the body weight nor food intake (Supplementary Figures S5A, B).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim accurately reflects the non-significant finding using appropriate associative language without overinterpretation.
More Accurate Statement
“In apolipoprotein E-deficient mice on a high-fat high-cholesterol diet, MPE-298 treatment is associated with no significant change in body weight or food intake compared to vehicle controls.”
Evidence from Studies
Supporting (0)
Contradicting (1)
The study didn’t measure whether the mice got heavier or ate more or less, so we can’t say if the treatment affected their weight or appetite — the claim can’t be proven with the info given.