When male mice get really high doses of statins, they act differently — like moving less or exploring less — and their brain chemistry changes too. Scientists think the way statins affect a certain brain enzyme might be why this happens.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

15

Adverse neurobehavioral changes with reduced blood and brain cholinesterase activities in mice treated with statins

Cross-Sectional Study

Animal

2024 Jan

The study gave high doses of statins to mice and found they acted slower and explored less, which matched lower levels of a brain enzyme. This supports the idea that the behavior changes were linked to the enzyme drop.

Contradicting (0)

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No contradicting evidence found

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Source Study

Adverse neurobehavioral changes with reduced blood and brain cholinesterase activities in mice treated with statins

Score: 15

DOI: 10.14202/vetworld.2024.82-88

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