The total amount of work done (weight × reps × sets) seems to matter for muscle growth — more work generally leads to more muscle, even if the weights are light.
Scientific Claim
Training volume-load appears to influence skeletal muscle hypertrophy, as three of the included studies showed greater gains with higher volume-load, even when load was low.
Original Statement
“Three of the studies were not volume equated, indicating a dose–response relationship between training volume-load and skeletal muscle hypertrophy.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design cannot support claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The term 'dose–response relationship' implies causation, but the included studies' designs are not confirmed as experimental or controlled. Only an association can be reliably stated.
More Accurate Statement
“Training volume-load is associated with greater skeletal muscle hypertrophy in resistance-trained men, based on findings from three non-volume-equated studies.”
Evidence from Studies
Supporting (1)
The Effect of Low-Load Resistance Training on Skeletal Muscle Hypertrophy in Trained Men: A Critically Appraised Topic.
Even with light weights, lifting more times until you're tired can build muscle just as well as heavy weights—because doing more total work (volume) matters more than how heavy the weight is.