Thyroid hormone might directly boost a bone enzyme in lab-grown rat bone cells at levels seen in people with an overactive thyroid, which could explain why those patients often have high bone enzyme levels.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors.

Cross-Sectional Study

In Vitro

1987 May

The study shows that thyroid hormone increases a bone enzyme in rat bone cells through a specific receptor, at hormone levels seen in people with Graves’ disease, which supports the idea that this is why the enzyme is high in hyperthyroid patients.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Thyroid hormone stimulates alkaline phosphatase activity in cultured rat osteoblastic cells (ROS 17/2.8) through 3,5,3'-triiodo-L-thyronine nuclear receptors.

Score: 3

DOI: 10.1210/ENDO-120-5-1873

Similar Assertions

Thyroid hormones seem to turn up the activity of a bone-building enzyme in rat bone cells, even at low levels—kind of like a volume knob for bone growth.

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80%

When someone has an overactive thyroid, their high alkaline phosphatase levels are usually because of faster bone turnover, not liver problems — thyroid hormones speed up how bones break down and rebuild.

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