mechanistic
Analysis v1
Strong Support
When a cell gets stretched and its internal scaffolding gets damaged, it needs to turn off a specific molecular brake (mTORC1) right where the damage happened to start cleaning up the mess — otherwise, it won’t begin its self-repair process.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.
Cross-Sectional Study
Human
2017 JanWhen muscles are stretched, a protein called BAG3 helps stop a growth signal (mTORC1) right where damaged filamin is found, which turns on the cell’s cleanup system (autophagy) to remove the damage — exactly what the claim says.
Contradicting (0)
0
Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.