Using a mild acne cream with tretinoin (up to 0.1%) for up to two years is usually fine for most people — you might get a little redness, peeling, or dryness at first, but it’s usually not bad enough to make you stop using it.

Using a special cream with tretinoin (0.025% to 0.1%) every day or every other day for up to two years can noticeably reduce sun damage like wrinkles, dark spots, and dull skin — and you might start seeing results in just one month.

Using a cream with tretinoin in strengths between 0.025% and 0.1% can really help reduce sun damage on your skin, but the super weak 0.01% version doesn’t do much—plus, a strong 5% peel works just as well for looks but changes your skin’s inner structure differently.

If you're using a skin cream to fix sun damage, adapalene and tretinoin are about equally gentle on your skin after using them every day for six months — neither causes much more irritation than the other.