When antibodies stick to germs and bind to certain receptors on immune cells, the cell swallows the whole thing into a bag that goes to a trash compactor (lysosome) to break it down for display.
Scientific Claim
Cross-linking of activating FcγRs triggers clathrin-mediated endocytosis of IgG immune complexes, leading to their trafficking to lysosomes for antigen processing and MHC class II loading.
Original Statement
“Cross-linking of activating FcγRs leads to ITAM phosphorylation and clathrin-mediated internalization of the FcγR:IgG-IC aggregate with subsequent IgG-IC transport to lysosomes. ... Inside the lysosomal compartment, both FcγRs and the internalized antigen are proteolytically degraded and eventually loaded onto MHC class II complexes, processes that depend on cathepsin, and HLA-DM activity.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The claim describes a well-established endocytic pathway supported by direct experimental evidence from multiple primary studies cited. Definitive language is appropriate for this conserved cellular mechanism.
Evidence from Studies
Supporting (1)
When antibodies stick to germs, special receptors on immune cells grab them and pull them inside, where the germs get broken down and shown to other immune cells to trigger a bigger response.