Analysis Version
v1
History
Back to Study: Cideb knockdown in mice increases mitochondrial fa...
mechanistic
Analysis v1
Strong Support

When Cideb was reduced, the mice’s livers made less new fat from scratch, which helped them store less fat overall.

12
Pro
0
Against

Evidence from Studies

Supporting (1)

12

Community contributions welcome

12

Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway

Cohort Study
Animal
2025 Dec

The study found that turning off the Cideb gene in obese mice made their livers store less fat, partly because the liver made less new fat — exactly what the claim says.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Cideb knockdown in mice increases mitochondrial fat oxidation and reverses hepatic steatosis and insulin resistance by the plasma membrane sn-1,2-DAGs–PKCε–insulin receptor kinaseT1150 pathway

Score: 12
DOI: 10.1007/s00125-025-06539-8

Similar Assertions

When scientists reduced a specific protein called Cideb in obese mice, their livers stored much less fat because the liver started burning more fat and making less new fat.

12
0
91%

The livers of mice with less Cideb burned more fat for energy, producing more ketones and running their energy factories (mitochondria) faster.

12
0
85%

Mice with less Cideb protein burned more calories overall, even when eating the same high-fat diet as other mice.

12
0
84%

The livers of mice eating olive oil and nuts turned off genes that make fat, compared to mice eating a fatty diet, which may help explain why they had less fat in their blood.

0
15
76%

When Cideb was reduced in obese mice, their bodies responded better to insulin because harmful fat molecules in cell membranes dropped, which helped insulin signaling work better in liver and muscle.

12
0
75%