When healthy women eat nutrition bars with 0, 2, or 3 grams of added leucine peptide, their blood leucine levels rise proportionally to the dose, but their feelings of fullness and peptide YY levels...

Pro

Against

Mechanism

Synthesis from 1 study

How it works

After eating leucine, blood levels of leucine go up and the brain detects this change, which makes you feel less hungry and more full. This happens even though a hormone called PYY, which usually signals fullness, does not change at all.

Most probable mechanism

In Simple Terms

When leucine enters the bloodstream after eating, it triggers signals in the brain that reduce hunger and increase fullness without changing the levels of the hormone PYY.

Causal chain

Leucine peptide is digested and absorbed from the gastrointestinal tract, causing a dose-dependent increase in plasma leucine concentration

Verified by multiple studies

which leads to

Elevated plasma leucine activates nutrient-sensing pathways in the brain, including the hypothalamus, leading to altered neural signaling that reduces hunger and increases fullness

Supported by evidence

which leads to

Peptide YY is not secreted in proportion to plasma leucine levels, and its concentration in the blood remains unchanged despite measurable changes in appetite sensations

Verified by multiple studies

Evidence from Studies

Supporting (1)

Community contributions welcome

Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women.

Randomized Controlled Trial

Human

2018 May 1

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Consuming Lower-Protein Nutrition Bars with Added Leucine Elicits Postprandial Changes in Appetite Sensations in Healthy Women.

Score: 59

DOI: 10.1093/jn/nxy023

Similar Assertions

In healthy women, consuming 2 or 3 grams of leucine peptide does not change levels of the gut hormone PYY after eating, compared to a control bar.

89%

In healthy women, consuming a 3-gram leucine peptide supplement does not reduce hunger or desire to eat more than a control bar, even though it raises blood leucine levels more than a 2-gram dose, showing that higher leucine levels do not proportionally reduce appetite.

84%

Consuming a nutrition bar with 3 grams of leucine peptide raises plasma leucine levels by 260% compared to a bar with no leucine peptide in healthy women, but does not increase feelings of fullness.

81%

A nutrition bar with 11 grams of protein and 2 grams of leucine peptide produces the same level of fullness after eating as a bar with 13 grams of protein and 3 grams of leucine peptide in healthy women.

78%

Eating leucine-enriched nutrition bars with 0, 2, or 3 grams of leucine does not change how hungry healthy women feel shortly after consumption.

78%