mechanistic
Analysis v1
Strong Support
When obese men lose weight, a specific gene in their fat cells called 11β-HSD-1 becomes less active — and this seems to happen because they’re losing fat, not because the gene caused them to gain weight in the first place.
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Evidence from Studies
Supporting (1)
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Community contributions welcome
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After men lost weight, a gene called 11β-HSD-1 in their fat tissue went down — and it dropped because they lost fat, not because it caused the fat gain. So the gene is a result of weight loss, not the reason they got fat.
Contradicting (0)
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Community contributions welcome
No contradicting evidence found
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.