When mice with a lupus-like disease eat a lot of salt for months, they make more of the harmful antibodies that attack their own body, even though their blood pressure and kidney damage don't get worse.

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Evidence from Studies

Supporting (1)

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Blood pressure and albuminuria in a female mouse model of systemic lupus erythematosus: Impact of long-term high salt consumption.

Cohort Study

Animal

2020 Oct 1

Scientists gave lupus-prone female mice a lot of salt for 24 weeks and found they made more harmful antibodies that attack their own bodies — exactly what the claim said would happen.

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Source Study

Blood pressure and albuminuria in a female mouse model of systemic lupus erythematosus: Impact of long-term high salt consumption.

Score: 13

DOI: 10.1152/ajpregu.00070.2020

Similar Assertions

Even though salt is known to trigger inflammation through a protein called SGK1, in these lupus mice, eating a lot of salt didn’t change SGK1 levels in the kidney’s inner part — suggesting this pathway isn’t involved here.

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When mice with lupus eat a lot of salt, their kidneys make less of a signaling molecule called IL-2, which might reduce inflammation — even though their immune system is more active overall.

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