When rats eat too much salt, their body releases a hormone that tightens blood vessels — blocking that hormone’s effect cuts the blood pressure rise in half.

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Evidence from Studies

Supporting (1)

14

Community contributions welcome

14

High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.

Cohort Study

Animal

2015 Feb 4

Eating too much salt makes a brain signal (vasopressin) go up, which raises blood pressure. This study shows how salt causes that signal to get stronger, which supports the idea that blocking part of that signal can lower the pressure.

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No contradicting evidence found

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Source Study

High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.

Score: 14

DOI: 10.1016/j.neuron.2014.12.048

Similar Assertions

Rats that eat too much salt for a week have overactive brain cells that pump out more of a hormone that tightens blood vessels, causing their blood pressure to rise — but if you block that hormone, the pressure doesn’t go up as much.

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When rats eat too much salt, the brain cells that release a hormone to raise blood pressure start firing faster, and this directly causes their blood pressure to go up.

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When rats eat too much salt, their brain’s natural blood pressure control system flips — instead of slowing down when blood pressure rises, the neurons that release the pressure-raising hormone get even more active.

14

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