When scientists block the TRPM2 sensor, the chemical that normally warms up the mice no longer works — the body temperature stays the same.

10

Pro

0

Against

Evidence from Studies

Supporting (1)

10

Community contributions welcome

10

The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis

Randomized Controlled Trial

Animal

2025 Sep

The study found that blocking a specific protein (TRPM2) in brain cells stops the body from warming up when a certain chemical (ADPR) is given, proving that this protein is needed for the body to generate heat.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Source Study

The potential role of hypothalamic POMCTRPM2 in interscapular BAT thermogenesis

Score: 10

DOI: 10.1038/s12276-025-01538-6

Similar Assertions

When scientists turn on POMC brain cells with a chemical switch, mice get warmer — but if you block TRPM2 first, they don’t warm up at all.

10

0

82%

Even in overweight mice, the brain’s TRPM2 sensor still works — it can still turn on heat production in fat tissue.

10

0

71%