mechanistic
Analysis v1
Strong Opposition
When scientists removed the mitochondria’s DNA from human cells, the MOTS-c peptide disappeared—proving it comes from the mitochondria, not the cell’s main DNA.
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Evidence from Studies
Supporting (0)
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Community contributions welcome
No supporting evidence found
Contradicting (1)
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Community contributions welcome
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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
Randomized Controlled Trial
Animal
2015 Mar 3The study says MOTS-c comes from mitochondria, but it never tested cells that have no mitochondrial DNA, so we can't be sure it disappears without it.