When mice with hardened arteries and ongoing stress get regular exercise, their artery plaques become smaller and more stable, thanks to a specific biological switch being turned off.

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Pro

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Evidence from Studies

Supporting (1)

27

Community contributions welcome

27

Physical exercise mitigates chronic psychological stress‐induced vascular inflammation via the BDNF–Kif4–TARM1 axis

Randomized Controlled Trial

Human

2026 Apr

Exercise helps calm down harmful immune cells in stressed mice with clogged arteries, and it does this by turning off a specific molecular switch called Kif4–TARM1. This makes the plaques less likely to rupture, which is good for heart health.

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Source Study

Physical exercise mitigates chronic psychological stress‐induced vascular inflammation via the BDNF–Kif4–TARM1 axis

Score: 27

DOI: 10.1002/ctm2.70674

Similar Assertions

When mice under long-term stress and with clogged arteries get to run on a wheel, their body produces a protein that calms down harmful immune cells, which helps reduce artery inflammation and keeps plaques from becoming dangerous.

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