When the balance of omega-3 to omega-6 fats in body fat improves, there are fewer inflammation-causing immune cells — meaning omega-3s may help calm inflammation.
Scientific Claim
The n-3 to n-6 fatty acid ratio in human adipose tissue phospholipids is inversely correlated with the proportion of proinflammatory macrophages, suggesting a potential anti-inflammatory effect of higher n-3 intake.
Original Statement
“A very significant inverse correlation between the proportion of PIMs and the n-3/n-6 fatty acid ratio was found.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The correlation is observed, not manipulated; the study does not prove that changing the ratio causes reduced inflammation.
Evidence from Studies
Supporting (1)
Rapid Drop in Coronary Heart Disease Mortality in Czech Male Population—What Was Actually behind It?
When people ate less animal fat and more healthy fats like those in fish, their body’s inflammatory cells calmed down, which helped lower heart disease rates.