When doctors blocked a chemical called nitric oxide in healthy people, their hearts pumped less blood with each beat and overall, showing that this chemical helps keep the heart working normally when we're just resting.

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Pro

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Evidence from Studies

Supporting (1)

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Community contributions welcome

40

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

Cross-Sectional Study

Human

1994 May

The study gave a drug that blocks nitric oxide in healthy people and found their hearts pumped less blood, just like the claim says. This shows nitric oxide helps keep the heart working normally.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans.

Score: 40

DOI: 10.1161/01.CIR.89.5.2035

Similar Assertions

In healthy people, a substance in blood vessels called nitric oxide helps keep blood pressure and vessel tightness in check. When scientists blocked this substance, blood vessels tightened up and blood pressure went up, showing how important it is for keeping things normal.

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In healthy people, a molecule called nitric oxide helps keep blood vessels in the lungs open and relaxed when oxygen levels are normal. When scientists blocked its production, the lung blood vessels became more resistant to blood flow, even though overall pressure didn’t change.

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