When you lift weights, your muscles sense the tension and turn on internal signals that help them grow bigger—and they might even become better at using leucine, a protein-building block, to help with that growth.

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Evidence from Studies

Supporting (1)

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An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

Narrative Review

2022 Sep 1

This study says lifting weights causes muscles to grow by activating internal body signals — and the claim says one of those signals involves specific proteins that help muscles respond to protein (like leucine). Since the study confirms the general idea that weightlifting triggers these growth signals, it supports the claim.

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Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy

Score: 1

DOI: 10.1249/mss.0000000000002929

Similar Assertions

When you lift weights, the pulling force on your muscles is what makes them grow bigger—not hormones or feeling tired. This force turns on internal signals that tell your muscles to make more protein and get larger over time.

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When you lift weights, the pulling force on your muscles is what makes them grow bigger—not because of hormones or feeling burned out, but because your muscles sense the tension and respond by building more muscle fibers.

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When you lift weights, the pulling force on your muscles is what makes them grow bigger—not because of hormones or feeling tired, but because your muscles sense the tension and respond by building more muscle fibers.

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Lifting weights makes your muscles bigger, mostly because it turns on a special signal in your muscle cells that tells them to make more protein, but other things might help too.

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