Whether you rest 1 minute or 2 minutes between squat sets, your muscles get about the same amount of oxygen during the exercise, even if you're at high altitude or breathing normal air.

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Inter-set rest configuration effect on acute physiological and performance-related responses to a resistance training session in terrestrial vs simulated hypoxia

Randomized Controlled Trial

Human

2022

The study looked at how resting 60 vs 120 seconds between sets affects muscle oxygen levels during squats, but it didn’t clearly say whether the rest time made a difference — so we can’t say if the claim is right or wrong.

Source Study

Inter-set rest configuration effect on acute physiological and performance-related responses to a resistance training session in terrestrial vs simulated hypoxia

Score: 49

DOI: 10.7717/peerj.13469

Similar Assertions

When you do squats without fully straightening your knees and restrict blood flow, your thigh muscle gets much less oxygen during the exercise than when you're just sitting still.

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Even short, locked squats (8 seconds) can make your thigh muscle very low on oxygen — but only if you keep your knees bent and restrict blood flow.

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Breathing air with less oxygen through a mask (simulated altitude) makes your muscles get less oxygen during exercise than being at real high altitude, even when the oxygen level in the air is the same.

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When you restrict blood flow to your thigh while squatting, your muscle gets much less oxygen — no matter how you move your knee.

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