When cells are stretched or pushed, a protein called BAG3 grabs onto two other proteins (TSC1/TSC2) that normally slow down protein production. This lets the cell make more proteins, as if it’s hitting the gas pedal.

20

Pro

0

Against

Evidence from Studies

Supporting (1)

20

Community contributions welcome

20

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Cross-Sectional Study

Human

2017 Jan

When muscles are strained, a protein called BAG3 moves away some inhibitors of protein-making machinery, letting the cell build more proteins where needed — just like moving obstacles out of the way so a factory can run faster.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1.

Score: 20

DOI: 10.1016/j.bbamcr.2016.10.007

Similar Assertions

A protein called BAG3 acts like a magnet to grab another protein called TSC1, and together they help move a team of proteins to special cable-like structures in cells when those cells are stretched or pulled.

20

0

78%