While body fat percentage was genetically linked to heart disease and diabetes risk, the data didn't support that body fat directly causes these conditions.
Scientific Claim
Genetic correlation between body fat percentage and cardiometabolic traits was observed, but causal inference models (LCV) indicated no evidence of causation (genetic causality proportion <0.6 for all outcomes).
Original Statement
“Using the LCV model, we found positive genetic correlations between BFPAdj and T2D and CAD, and a negative genetic correlation between BFPAdj and HDL, yet no evidence suggested causal effect of BFPAdj on these traits (all estimated gcp<0.6; Table S8).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim accurately reports the LCV results without implying causation, using appropriate association language for observational data.
Evidence from Studies
Supporting (1)
Beyond apples and pears: sex-specific genetics of body fat percentage