Women with fibromyalgia report more pain and fatigue during intense exercise than women without the condition, even though both groups show similar rises in a blood protein called IGF-1, suggesting that how the body responds chemically doesn't always match how much discomfort a person feels.

40

Pro

0

Against

Evidence from Studies

Supporting (1)

40

Community contributions welcome

40

Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia

Randomized Controlled Trial

Human

2017 Jan 25

Women with fibromyalgia felt more pain and tiredness during exercise than healthy women, even though their bodies responded the same way—producing similar levels of a muscle-related protein called IGF-1. So, their bodies worked fine, but they just felt worse.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia

Score: 40

DOI: 10.1186/s12891-017-1402-y

Similar Assertions

Women with fibromyalgia show the same short-term rise in two specific blood proteins (IGF-1 and IGFBP-3) during exercise as healthy women, even though they exercise at lower intensities.

40

0

89%

In women with fibromyalgia, a 15-minute session of moderate exercise raises levels of IGF-1 and IGFBP-3 in the blood without changing markers of inflammation like CRP or IL-8, suggesting these hormonal changes happen without involvement of inflammatory processes.

40

0

84%

A 15-minute moderate cycling workout raises levels of insulin-like growth factor-1 (IGF-1) in the blood by about 11 ng/mL in women with fibromyalgia, and the increase is similar to that seen in women without fibromyalgia.

40

0

83%

In women with fibromyalgia and healthy women, a 15-minute session of moderate or high-intensity cycling raises IGF-1 levels in the blood by a similar amount, regardless of how much body fat they have.

40

0

83%