Women with PCOS are more sensitive to the negative effects of fat in the blood — their muscles struggle much more to use sugar when fat levels rise, compared to women without PCOS.

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Pro

45

Against

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

45

Community contributions welcome

45

Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS

Randomized Controlled Trial

Human

2018

The study found that women with PCOS were more sensitive to fat-induced insulin resistance than others — but only before exercise. After exercise, this difference disappeared, meaning the higher sensitivity isn’t a fixed trait, which contradicts the claim that PCOS women are inherently more vulnerable.

Gold Standard Evidence Needed

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Source Study

Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS

Score: 45

DOI: 10.3389/fendo.2018.00592

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45

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