If you're a young, fit guy who already lifts weights, doing more weight training for 12 weeks won't change how many androgen receptors are in your muscles—but the number you started with can tell you how much bigger your muscles will get.

A prospective, single-blind RCT with 40 healthy, young, resistance-trained men randomly assigned to 12 weeks of standardized resistance training (3x/week, 70-85% 1RM, 3-5 sets, 6-12 reps) with pre- and post-intervention muscle biopsies to measure androgen receptor content via Western blot and immunohistochemistry, and muscle hypertrophy quantified via DEXA or MRI. Baseline androgen receptor levels are correlated with hypertrophy change.

A prospective cohort study tracking 60 healthy, young, resistance-trained men over 12 weeks of unsupervised resistance training, collecting serial muscle biopsies to measure androgen receptor content and muscle size changes, with statistical analysis of whether baseline receptor levels predict hypertrophy magnitude.

A case-control study comparing men with high vs. low muscle hypertrophy after 12 weeks of resistance training, measuring baseline androgen receptor content to determine if it differs between groups.

A cross-sectional snapshot of androgen receptor content and muscle size in a group of resistance-trained men, attempting to infer whether baseline levels predict hypertrophy by correlating current receptor levels with current muscle size.