Your muscles make more protein at first when you start lifting weights, but after a few weeks, that boost fades—even if you keep lifting harder.

Scientific Claim

Myofibrillar protein synthesis rates increase during resistance training but decline from week 1 to week 10 despite progressive overload, indicating an adaptive blunting of the muscle-building signal over time.

Original Statement

“Rates of MyoPS in weeks 1 and 10 of training were increased relative to rest (Week 1: Δ0.27 ± 0.11, P < 0.0001; Week 10: Δ0.10 ± 0.14%/d, P = 0.009); however, MyoPS was attenuated in week 10 versus week 1 (Δ0.16 ± 0.18%/d, P < 0.001).”

From study:Resistance training load does not determine resistance training-induced hypertrophy across upper and lower limbs in healthy young males.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The claim is based on direct, repeated-measure biochemical data with statistical significance reported. The verb 'declines' is appropriate given the within-subject longitudinal design and clear p-values.

Evidence from Studies

Supporting (1)

Resistance training load does not determine resistance training-induced hypertrophy across upper and lower limbs in healthy young males.

Randomized Controlled Trial

Human

2025 Dec 31

Contradicting (0)

No contradicting evidence found

Source Study

Resistance training load does not determine resistance training-induced hypertrophy across upper and lower limbs in healthy young males.

Score: 46

DOI: 10.1113/JP289684

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