Zerumbone stops skin cells from making too much of an enzyme that breaks down collagen, helping keep skin structure intact after UVA exposure.

Scientific Claim

Zerumbone at 8 μM inhibits UVA-induced MMP-1 upregulation and prevents collagen III degradation in human skin fibroblasts, preserving extracellular matrix integrity.

Original Statement

“ZER pretreatment attenuated the UVA-induced MMP-1 expression and reversed the degradation of its target protein collagen III (Figures 1(c) and 1(d)).”

From study:Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

Protein expression levels of MMP-1 and collagen III were directly measured and quantified with statistical significance; the claim accurately reflects the data.

Evidence from Studies

Supporting (1)

Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway

Cross-Sectional Study

In Vitro

The study shows that a natural compound called zerumbone, at a specific dose, protects skin cells from sun damage by stopping harmful enzymes from breaking down collagen, which keeps skin firm and young-looking.

Contradicting (0)

No contradicting evidence found

Source Study

Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway

Score: 5

DOI: 10.1155/2019/4098674

Similar Assertions

Zerumbone helps skin cells in a dish clean up harmful molecules (ROS) that are made when they’re exposed to UVA light—more zerumbone means less damage.

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Zerumbone blocks the activation of two proteins (c-Fos and c-Jun) that tell skin cells to break down collagen when exposed to UVA light.

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A natural compound called zerumbone, when applied to skin cells in a lab, helps them survive better after being exposed to UVA light—especially at higher doses.

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When skin cells are damaged by UVA light, they start acting old—zerumbone helps them stay young by reducing this 'aging marker' by more than half.

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Zerumbone slightly increases harmful molecules (ROS) in skin cells before UVA hits—this small rise is actually needed to activate the cell’s defense system.

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