Does daily 100 mg aspirin increase bleeding risk in adults over 70?

Daily administration of 100 mg enteric-coated aspirin significantly increases the risk of major hemorrhage, defined as hemorrhagic stroke, symptomatic intracranial bleeding, or clinically significant extracranial bleeding requiring transfusion, hospitalization, surgery, or resulting in death, in healthy community-dwelling adults aged 70 years and older. Over a median follow-up of 4.7 years, the event rate was 8.6 per 1000 person-years in the aspirin group compared to 6.2 per 1000 person-years in the placebo group, yielding a hazard ratio of 1.38 (95% CI 1.18 to 1.62; P<0.001).