Does daily low-dose aspirin prevent heart disease in adults over 70?

Daily administration of 100 mg enteric-coated aspirin does not significantly reduce the risk of cardiovascular disease, defined as a composite of fatal coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal stroke, or hospitalization for heart failure, in healthy community-dwelling adults aged 70 years and older. Over a median follow-up of 4.7 years, the event rate was 10.7 per 1000 person-years in the aspirin group versus 11.3 per 1000 person-years in the placebo group, yielding a hazard ratio of 0.95 (95% CI 0.83 to 1.08), indicating no clinically meaningful protective effect in this demographic.