Does melatonin improve quality of life in heart failure patients?

Oral melatonin supplementation administered at doses ranging from 3 to 20 milligrams daily for treatment periods of 8 to 24 weeks significantly improves health-related quality of life in adults diagnosed with heart failure. Pooled analysis demonstrates a mean difference of -5.95 points on validated patient-reported outcome questionnaires compared to placebo, indicating that melatonin therapy may serve as a beneficial adjunctive treatment to alleviate the psychological and physical burdens associated with chronic cardiac dysfunction.