Does melatonin reduce inflammatory cell death in blood vessel cells exposed to oxidized LDL?

Melatonin treatment significantly reduces the expression of key pyroptosis-associated genes, including NLRP3, caspase-1, and IL-1β, in human umbilical vein endothelial cells that have been exposed to oxidized low-density lipoprotein. This genetic modulation indicates that melatonin exerts a protective effect against inflammatory cell death pathways within the vascular endothelium, potentially mitigating early stages of atherosclerotic plaque formation by preserving endothelial integrity.