Does melatonin supplementation improve cholesterol levels?

45
Pro
0
Against
Leans yes
2 min readUpdated May 17, 2026

What the Evidence Shows

Our current analysis shows that melatonin supplementation appears to have a positive effect on cholesterol levels. The evidence we have reviewed leans toward melatonin helping to improve these numbers.

We analyzed the available research and found that forty-five studies support the idea that taking melatonin might help improve cholesterol. Zero studies refute this finding. Our review indicates that melatonin could lower the types of cholesterol that are often linked to heart concerns, while raising the type that helps protect your heart. These adjustments are generally small. The evidence also suggests that melatonin does not seem to change triglyceride levels, which are another type of fat found in your blood. What we have found so far points to a potential benefit for heart health, though the changes are modest. We want to be clear that this is a partial view. Our analysis improves over time as new research becomes available. The evidence we have reviewed leans toward a positive effect, but we cannot say this is set in stone. Not every study has looked at the same markers, and the overall picture is still taking shape.

If you are considering melatonin for your cholesterol, it may be worth discussing with a healthcare provider. You can track your levels with a simple blood test to see how your body responds. Making steady lifestyle choices around diet and movement will continue to be the most reliable way to support your heart.

Update History

Published
May 17, 2026·Last updated May 17, 2026