Vinegar's secret ingredient may calm angry artery cells
Orally administrated acetate inhibits atherosclerosis progression through AMPK activation via GPR43 in plaque macrophages.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Acetate’s anti-atherosclerotic effect requires GPR43—without it, the benefit disappears entirely.
Many assume dietary compounds work broadly, but here, a single receptor is non-negotiable—suggesting individual genetic differences could determine if vinegar helps or not.
Practical Takeaways
Add a splash of vinegar to water or food as part of a heart-healthy diet.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Acetate’s anti-atherosclerotic effect requires GPR43—without it, the benefit disappears entirely.
Many assume dietary compounds work broadly, but here, a single receptor is non-negotiable—suggesting individual genetic differences could determine if vinegar helps or not.
Practical Takeaways
Add a splash of vinegar to water or food as part of a heart-healthy diet.
Publication
Journal
Atherosclerosis
Year
2024
Authors
Toshiaki Wada, Takafumi Senokuchi, Yu Shi, Tatsuya Furusho, Yutaro Morita, Maeda Sarie, Satoko Hanatani, K. Fukuda, Norio Ishii, T. Matsumura, Yukio Fujiwara, Yoshihiro Komohara, Eiichi Araki, Naoto Kubota
Related Content
Claims (4)
When you eat vinegar, your body turns it into a substance called acetate, which tricks your cells into thinking they're low on energy—so they start burning fat for fuel instead.
Giving mice a common food ingredient called sodium acetate by mouth seems to help reduce fatty buildups in their arteries by calming down immune cells and reducing harmful chemicals in their bodies.
A natural substance called acetate may calm down harmful immune cells in clogged arteries by flipping a biological switch called AMPK, which helps reduce swelling and damage.
In mice, a natural chemical called acetate helps prevent fatty buildup in arteries, but only if a specific protein (GPR43) is present in certain immune cells—when that protein is missing, acetate doesn’t work anymore.