A shot that slashes a dangerous cholesterol
Small Interfering RNA to Reduce Lipoprotein(a) in Cardiovascular Disease.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested a new shot called olpasiran that tells the liver to make less of a harmful fat called lipoprotein(a).
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 566 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested a new shot called olpasiran that tells the liver to make less of a harmful fat called lipoprotein(a).
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 566 / 90
Evidence Score
Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.
Publication
Authors
O'Donoghue ML, Rosenson RS, Gencer B, López JAG, Lepor NE, Baum SJ, Stout E, Gaudet D, Knusel B, Kuder JF, Ran X, Murphy SA, Wang H, Wu Y, Kassahun H, Sabatine MS, OCEAN(a)-DOSE Trial Investigators
Related Content
Claims (3)
A new shot called olpasiran can slash a dangerous type of cholesterol called lipoprotein(a) by more than double its starting level in people with heart disease — meaning it doesn’t just lower it, it nearly wipes it out.
A new drug called olpasiran can dramatically lower a harmful type of cholesterol called lipoprotein(a) in people with heart disease — at the highest dose, it doesn’t just reduce it, it nearly wipes it out completely compared to a dummy pill.
For people with heart disease and high levels of a fatty protein called lipoprotein(a), a new drug called olpasiran mostly caused only mild reactions at the injection site, like redness or soreness, and was otherwise safe to use.