Why eating more protein helps you eat less and lose weight

Original Title

A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations

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Summary

When people ate more protein and the same amount of carbs, they felt fuller and ate fewer calories without trying — and lost weight even though their hunger hormones acted like they should be eating more.

Proposed Mechanism
Increased central nervous system leptin sensitivity mediating satiety
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Quality Analysis
Methodology
59%
Moderate QualityOverall Score
Randomized Controlled TrialMedicine/Nutrition

Systematic Reviews & Meta-Analyses

Max 100

Randomized Controlled Trials

Max 90

Cohort Studies

Max 72

Case-Control Studies

Max 58

Cross-Sectional Studies

Max 44

Case Reports & Case Series

Max 30

Expert Opinion & Narrative Reviews

Max 5
StrongerWeaker
Randomized Controlled Trials
Level 1b
59

59 / 90

Evidence Score

Participants are randomly assigned to treatment or control groups, minimizing bias. Considered the gold standard for testing whether an intervention causes an effect.

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