Why your sugar and fat levels matter even if your bad cholesterol is low
Triglyceride-Glucose Index, LDL and Cardiovascular Outcomes in Chronic Stable Cardiovascular Disease: Results from the ONTARGET and TRANSCEND trials.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
High TyG didn’t increase cardiovascular risk in patients with LDL < 100 mg/dL.
Most research assumes all metabolic risk factors add up—this shows a clear cutoff where one risk factor (TyG) becomes irrelevant if another (LDL) is well managed.
Practical Takeaways
If you have heart disease and your LDL is above 100, ask your doctor for a fasting triglyceride and glucose test to calculate your TyG index.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
High TyG didn’t increase cardiovascular risk in patients with LDL < 100 mg/dL.
Most research assumes all metabolic risk factors add up—this shows a clear cutoff where one risk factor (TyG) becomes irrelevant if another (LDL) is well managed.
Practical Takeaways
If you have heart disease and your LDL is above 100, ask your doctor for a fasting triglyceride and glucose test to calculate your TyG index.
Publication
Journal
European journal of preventive cardiology
Year
2023
Authors
B. Haring, Helmut Schumacher, G. Mancia, Koon K. Teo, Eva M Lonn, F. Mahfoud, R. Schmieder, Johannes F. E. Mann, K. Sliwa, Salim Yusuf, Michael Böhm
Related Content
Claims (4)
Cardiovascular risk persists despite low LDL cholesterol levels if concomitant metabolic syndrome, hypertension, chronic inflammation, or dysglycemia remain unaddressed.
People with heart disease who have higher levels of triglycerides and blood sugar together are a bit more likely to have another serious heart problem, like a heart attack or stroke, than those with lower levels.
If someone with heart disease has their bad cholesterol (LDL) well controlled under 100, then their triglyceride and sugar levels (TyG) don’t seem to add much extra risk for heart problems.
People with heart disease who have higher levels of both triglycerides and blood sugar are about 30% more likely to have a heart attack than those with lower levels, even after accounting for other health factors.