Why your sugar and fat levels matter even if your bad cholesterol is low
Triglyceride-Glucose Index, LDL and Cardiovascular Outcomes in Chronic Stable Cardiovascular Disease: Results from the ONTARGET and TRANSCEND trials.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Even if your bad cholesterol is under control, high levels of fat and sugar in your blood might still raise your risk of heart attacks or strokes.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
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Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Even if your bad cholesterol is under control, high levels of fat and sugar in your blood might still raise your risk of heart attacks or strokes.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 547 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Haring B, Schumacher H, Mancia G, Teo KK, Lonn EM, Mahfoud F, Schmieder R, Mann JFE, Sliwa K, Yusuf S, Böhm M
Related Content
Claims (4)
Cardiovascular risk persists despite low LDL cholesterol levels if concomitant metabolic syndrome, hypertension, chronic inflammation, or dysglycemia remain unaddressed.
People with heart disease who have higher levels of triglycerides and blood sugar together are a bit more likely to have another serious heart problem, like a heart attack or stroke, than those with lower levels.
If someone with heart disease has their bad cholesterol (LDL) well controlled under 100, then their triglyceride and sugar levels (TyG) don’t seem to add much extra risk for heart problems.
People with heart disease who have higher levels of both triglycerides and blood sugar are about 30% more likely to have a heart attack than those with lower levels, even after accounting for other health factors.