Medicine helps liver fat in transplant patients
Saroglitazar improves nonalcoholic fatty liver disease and metabolic health in liver transplant recipients
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A medicine called saroglitazar was given to people who had liver transplants and had fatty liver. After 24 weeks, their liver fat went down on average. The medicine didn’t hurt their muscles and was generally safe.
Surprising Findings
Liver fat went down while belly fat went up — even though weight didn’t change.
It’s counterintuitive — people expect fat loss to be uniform or at least not redistribute to the belly. This suggests the drug may be shifting fat from the liver to the abdomen, which is unexpected.
Practical Takeaways
If you have fatty liver disease, especially after liver transplant, ask your doctor about saroglitazar — it may help reduce liver fat without harming muscle.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A medicine called saroglitazar was given to people who had liver transplants and had fatty liver. After 24 weeks, their liver fat went down on average. The medicine didn’t hurt their muscles and was generally safe.
Surprising Findings
Liver fat went down while belly fat went up — even though weight didn’t change.
It’s counterintuitive — people expect fat loss to be uniform or at least not redistribute to the belly. This suggests the drug may be shifting fat from the liver to the abdomen, which is unexpected.
Practical Takeaways
If you have fatty liver disease, especially after liver transplant, ask your doctor about saroglitazar — it may help reduce liver fat without harming muscle.
Publication
Journal
Liver Transplantation
Year
2023
Authors
M. Siddiqui, D. Parmar, Farheen S. Shaikh, M. Forsgren, S. Patel, A. Bui, Sherry L Boyett, V. Patel, A. Sanyal
Related Content
Claims (6)
Excess visceral, liver, and intramuscular fat represent a serious metabolic dysfunction that is not solely due to lack of discipline, and reducing these fat depots improves metabolic function and overall well-being, with muscle quality being a key factor in longevity.
For people who had a liver transplant and have fatty liver disease, taking saroglitazar for 24 weeks lowered the amount of fat in their liver from about 10% to 8% on average. This finding is from the abstract summary - full study details were not available
About half of all patients and over 60% of those with higher initial liver fat saw their liver fat drop by at least 30% after taking saroglitazar for 24 weeks. This finding is from the abstract summary - full study details were not available
When liver transplant patients with fatty liver disease had lower levels of a liver enzyme called alkaline phosphatase after treatment, their liver fat also tended to decrease more. This finding is from the abstract summary - full study details were not available
Taking saroglitazar didn't make the muscles weaker or more fatty in liver transplant patients with fatty liver disease. This finding is from the abstract summary - full study details were not available