Does too much insulin raise blood pressure in sick kidneys?
Chronic hyperinsulinemia and blood pressure regulation.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Chronic hyperinsulinemia did not elevate blood pressure even under high sodium intake or during ANG II-induced hypertension.
It contradicts the widely held belief that high insulin levels directly cause hypertension by increasing sodium retention and blood volume — especially in the context of obesity and kidney dysfunction.
Practical Takeaways
High insulin levels alone may not be the main driver of high blood pressure in people with obesity or insulin resistance.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Chronic hyperinsulinemia did not elevate blood pressure even under high sodium intake or during ANG II-induced hypertension.
It contradicts the widely held belief that high insulin levels directly cause hypertension by increasing sodium retention and blood volume — especially in the context of obesity and kidney dysfunction.
Practical Takeaways
High insulin levels alone may not be the main driver of high blood pressure in people with obesity or insulin resistance.
Publication
Journal
The American journal of physiology
Year
1990
Authors
J. Hall, T. Coleman, H. Mizelle, M. J. Smith
Related Content
Claims (4)
If your body has too much insulin for a long time, it can make your kidneys hold onto more salt, which increases your blood volume and raises your blood pressure—even if you're not eating too much salt.
In dogs with damaged kidneys and eating a lot of salt, pumping extra insulin into their blood for almost a month doesn’t raise their blood pressure — it stays normal, even though insulin levels go way up.
In dogs with badly damaged kidneys and a salty diet, giving insulin for a month boosts kidney filtering power without affecting key blood pressure hormones, suggesting insulin helps kidneys adapt on its own.
In dogs with most of their kidney removed, having high insulin levels didn’t make blood pressure go up any more when they were also given a blood-pressure-raising hormone — even though that hormone had already raised their blood pressure a bit on its own.