What does rapamycin do to old mouse muscles?
Rapamycin Treatment Induces Lipidomic and Metabolic Changes in Skeletal Muscle of Aged Mice with Hyperactive mTORC1
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Rapamycin increased harmful lipid types like diacylglycerols (DG) and cholesterol esters (CE), which are often linked to insulin resistance, rather than reversing them.
Rapamycin is often studied for its anti-aging benefits, so increasing metabolites associated with metabolic dysfunction is counterintuitive and unexpected.
Practical Takeaways
Understanding sex differences in drug response could inform personalized anti-aging therapies.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Rapamycin increased harmful lipid types like diacylglycerols (DG) and cholesterol esters (CE), which are often linked to insulin resistance, rather than reversing them.
Rapamycin is often studied for its anti-aging benefits, so increasing metabolites associated with metabolic dysfunction is counterintuitive and unexpected.
Practical Takeaways
Understanding sex differences in drug response could inform personalized anti-aging therapies.
Publication
Journal
Physiology
Year
2025
Authors
Hanna Kalenta, Rosario Maroto, Jacquelyn T. May, Jennifer J. Linares, Sean P. Kilroe, Erik D. Marchant, Trevor B. Romsdahl, W. Russell, Blake B. Rasmussen
Related Content
Claims (4)
Rapamycin might help older animals keep their muscle and stay lean by tweaking a key cell signal involved in aging.
In older mice with overactive muscle metabolism, giving them a drug called rapamycin changes the types of fats in their muscles — some go up, some go down — which might mean the drug helps reset how aging muscles handle fat.
Older mice with overactive mTORC1 had higher levels of certain muscle-related amino acid processes after taking rapamycin, which might help muscles handle stress and stay healthy.
Older male mice have bigger changes in muscle chemicals after taking rapamycin than older female mice, suggesting their bodies respond differently to this drug as they age.